Gholipour, N. (2012) Screening of transcription factor binding sites and E-boxes variants of Astrocyte elevated gene -1 and their association in hepatocellular carcinoma patient. Masters thesis, University of Zabol.
|
Text
Screening of transcription factor binding sites and E-boxes.pdf Download (137kB) | Preview |
Abstract
Each year, hepatocellular carcinoma is diagnosed in more than half a million people worldwide, Liver cancer is the fifth most common cancer in men and the seventh in women. Astrocyte elevated gene -1(AEG-1, also known as MTDH, and Lyric) has been demonstrated to play a potential role in several significant aspects of tumor progression. It has been reported that overexpression of AEG-1 is associated with progression of disease and poorer prognosis in hepatocellular carcinoma. However, there are no studies to date assessing variants of the AEG-1 gene and their potential relationship with hepatocellular carcinoma susceptibility. Thus, we investigated variants of the AEG-1 gene promoter and explored the association of the variants with hepatocellular carcinoma development. Our case and control consisted of gene promoter transcription factor binding site sequencing of 53 hepatocellular carcinoma cases and 108 healthy controls. Variants were detected in 11 hepatocellular carcinoma cancer cases and 3 controls. Among the variants discovered, 1 novel variants in AP2 transcription binding site that can be associated with the susceptibility of hepatocellular carcinoma (P <0.05) .However, additional studies need to be conducted in larger sample sizes to validate these findings and to further investigate whether these variants are prognostic in hepatocellular carcinoma patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | hepatocellular carcinoma, AEG-1, promoter, transcription factor |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Depositing User: | admin admin1 admin2 |
| Date Deposited: | 06 Nov 2016 07:20 |
| Last Modified: | 06 Nov 2016 07:20 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/975 |
Actions (login required)
 |
View Item |
