Yarmohammadi, Elahe (2020) Synthesis of 5-substituted 1,3,4-oxadiazole-2-thiol derivatives under ultrasound irradiation and evaluation of their antibacterial and antifungal effects. Masters thesis, University of Zabol.
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Synthesis of 5-substituted 1,3,4-oxadiazole-2-thiol derivatives under ultrasound irradiation and evaluation of their antibacterial and antifungal effects.pdf Download (335kB) | Preview |
Abstract
One of the goals of green chemistry is to use environmentally-friendly solvents or remove and reduce the volume of harmful organic solvents. In this study, a novel process for the synthesis of 5-HHHHHHHHHHH 1،3،4-HHHHHHHHHH-2-HHHHH HHHHHHHHHHH HHH HHHHHHHH HHH HHHHHHHHHH-HHHHHHHH HHHHHHHH of aryl hydrazides with CS2 (1:1 molar ratio) in some drops of DMF in the absence of basic or acidic catalysts. They were produced in good to excellent yields with an easy purification step. Their potential antibacterial and antifungal properties were then screened by serial two-fold microdilution and streak plate methods. Acceptable to significant inhibitory activities were observed with synthesized heterocycles. The results showed that 5-(4-fluorophenyl)-1,3,4-oxadiazole-2-thiol (3c) is an broad-spectrum antimicrobial agent.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | 1,3,4-Oxadiazole; Antibacterial; Antifungal; Green synthesis; Ultrasound |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 02 Oct 2022 08:03 |
| Last Modified: | 02 Oct 2022 08:03 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3125 |
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