Heydari, N. (2021) Evaluation of Hook gene expression changes in transgenic Aß and tau Drosophila models. Masters thesis, University of Zabol.
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Abstract
Alzheimer's disease is a neurodegeneration disorder with two main characteristics called beta amyloid plaques and neurofibrillary tangels composed of tau protein. Dysfunctional autophagy is also a feature of Alzheimer's disease. In Alzheimer's disease, amyloid beta and tau cause some sort disorder in autophagy . The Hook gene is one of the genes involved in the autophagy process. Hook gene expression proteins are involved in endosomal translocation, and decreased expression of this gene slows endosomal translocation and disrupts autophagy. In this study, we used Drosophila melanogaster as a model animal. And by creating transgenic strains expressing human amyloid beta and tau, we evaluated the changes in Hook gene expression in CNS tissues using Real Time PCR technique. The results showed that amyloid beta and tau each had different effects on Hook gene expression. the amyloid beta decreased and tau increased the expression of Hook , and this is due to differences in their mechanisms of action.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Alzheimer's disease, Aβ, Tau, autophagy, Hook gene, Drosophila melanogaster |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 24 Sep 2022 10:27 |
| Last Modified: | 24 Sep 2022 10:27 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3038 |
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