Effect of leaf alcoholic extract of prosopisfarcta on gene expression of phosphofrctokinase-1 in diabetic rats (type 1)

Harat Gholami, T. (2014) Effect of leaf alcoholic extract of prosopisfarcta on gene expression of phosphofrctokinase-1 in diabetic rats (type 1). Masters thesis, University of Zabol.

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Diabetes is one of serious clinical problems in all countries. Today the suffering from this problem, only because of this illness but also because of its side effects, increased. Plants as huge source of food supplements are helpful for controlling blood glucose and preventing from long- term effects. According to the diversity of herbs in Iran and their therapeutic potential and also possible risks of chemical drugs, by evaluation of herbs’ effects on diabetes we can find some new ways for treatment. Fruktokinaz enzyme-1 is one of cytosolic enzymes in glycolic way which has the key role in assigning glycosides. Some effects such as enzyme defect of pfk-1 in skeleton muscles can be recognizing by feeling tiered and decreasing muscle ability. In some cases also its defects cause fast growing of cancer cells. In this research we discussed about the effect of alcoholic extract of rattles plant leaves (because of anti-inflammatory, anti- microbus and anti- diabetes effects) in expressing pfk-1 gene in diabetic rats of first kind. In this survey 45 male rats categorized in to three groups randomly; normal control, diabetic control and treated diabetics by rattles extract. After Streptozotocin injection (60 mg/ kg) in male rats the first kind of diabetes produced. Treated diabetics group received rattles extract for 30 days. Normal group and diabetic group received distilled water. Then in the day before extract injection and 15 and 30 days after injection the glucose in blood determined and expression of PFK-1 liver gene evaluated by using Real- Time PCR method. Results showed that glucose in blood decreased in day 15. But there is no meaningful relation between diabetic group and treated one. Expressions of PFK gene in treated diabetic group in day 15 aren’t different from diabetic group. And also there wasn’t any meaningful different for PFK gene in groups. Therefore injection of hydraulic extract of rattles plant can influence expression of phosphor- fruktolinaz-1 in first kind of diabetes.

Item Type: Thesis (Masters)
Uncontrolled Keywords: rattles, phospho- frukto- kinaze-1, first kind of diabetes
Subjects: Q Science > QH Natural history > QH426 Genetics
Depositing User: admin admin1 admin2
Date Deposited: 23 May 2016 07:00
Last Modified: 23 May 2016 07:00
URI: http://eprints.uoz.ac.ir/id/eprint/629

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