Association study of rs165599 SNP in COMT gene in schizophrenic patients in Yasuj city (Iran)

Davari, E. (2014) Association study of rs165599 SNP in COMT gene in schizophrenic patients in Yasuj city (Iran). Masters thesis, University of Zabol.

Association study of rs165599 SNP.pdf

Download (134kB) | Preview


Schizophrenia is a serious mental illness, which began in late adolescence or early adult life. Although exact cause of schizophrenia is unknown, but studies have shown that genetic, environmental factors, and their interactions affect the development of the disease. Previous studies invistigated the genetic factors and environmental effects on the incidence of schizophrenia. Scientists identify candidate genes for schizophrenia which are called COMT. The gene encoding the catechol –omethyltransferase enzyme is involved in the metabolism of neurotransmitters catecholamines such as dopamine. This gene is located on chromosome 22 q11.21. This study invistigated the correlation between rs165599 polymorphism in the COMT gene and schizophrenia among the population of Yasuj city. To investigate the polymorphism gene 5 ml of blood from 100 patients and 100 healthy donors were drawn in EDTA tubes. Then, the DNA was extracted from the samples using PCR-RFLP techniques, it was genotype. The difference between the two groups of patients and the controls group were compared using Chi square test. All analyzes were performed using SPSS software. signification results were observed in the COMT gene and Schizophrenia rs165599 SNP.

Item Type: Thesis (Masters)
Uncontrolled Keywords: schizophrenia, polymorphism, COMT, PCR-RFLP
Subjects: Q Science > QH Natural history > QH426 Genetics
Depositing User: admin admin1 admin2
Date Deposited: 23 Apr 2016 08:18
Last Modified: 23 Apr 2016 08:18

Actions (login required)

View Item View Item