Heidari khabbaz, A. (2023) Investigating the effect of long-term administration of Caffeine nanocarrier, Sn-Fe nanostructures, and Co-Ni nanostructures on histopathological changes of kidney, liver, and heart of rats. Doctoral thesis, university of zabol.
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Investigating the effect of long-term administration of Caffeine nanocarrier, Sn-Fe nanostructures, and Co-Ni nanostructures on histopathological changes of kidney, liver, and heart of rats.pdf Download (170kB) | Preview |
Abstract
Today, with the development of the production and consumption of nanoparticles, the concern regarding their negative side effects on the health of humans and other organisms has increased. Although some researchers consider nanoparticles as non-toxic compounds, some other studies have reported their toxic effects. Therefore, the aim of this study was to investigate the effect of long-term administration of caffeine nanocarriers and tin-iron (Sn-Fe) and cobalt-nickel (Co-Ni) nanocarriers on the histopathological changes of the kidney, liver and heart of rats. For this purpose, 40 healthy and adult male rats were purchased. These rats were divided into four groups; control, receiving caffeine nanoemulsion, receiving Sn-Fe nanocarrier and receiving Co-Ni nanocarrier. At the end of the experimental period, the combination of ketamine (75 mg/kg) + xylazine (10 mg/kg) was used to induce anesthesia and tramadol injection solution (2 mg/kg) was used to create analgesia. Then, tissue sampling, histopathologic assessment and blood serum analysis were performed. Finally, the obtained data were statistically analyzed. The results obtained in the present study indicated that all the investigated groups do not show the same effects, so that the least complication was related to caffeine nanoparticle, while tin-iron nanoparticle (Sn-Fe) caused the most complication. Generally, the results of our study showed that metal nanoparticles cause more destructive effects and to use these nanoparticles, the dosage and time of use should be taken into consideration. According to these results, conducting more studies to determine the appropriate dose of nanoparticles and also to determine the side effects of these nanoparticles should be considered and evaluated.
| Item Type: | Thesis (Doctoral) |
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| Uncontrolled Keywords: | caffeine, nanoparticle, liver, kidney, heart |
| Subjects: | S Agriculture > SF Animal culture |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 14 Oct 2024 20:12 |
| Last Modified: | 14 Oct 2024 20:12 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3686 |
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