Fakhireh, Vajihe (2023) Comparison of the efficiency of liquid-liquid microextraction methods using deep eutectic solvents and switchable hydrophilicity solvents for measuring some pharmaceutical compounds. Masters thesis, university of zabol.
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Comparison of the efficiency of liquid-liquid microextraction methods using deep eutectic solvents and switchable hydrophilicity solvents for measuring some pharmaceutical compounds.pdf Download (302kB) | Preview |
Abstract
In this research, the effectiveness of two methods of liquid phase microextraction with an ectatic solvent and liquid phase microextraction with a solvent with variable hydrophilicity was investigated in the extraction and measurement of imipramine. in microextraction with an ectatic solvent 4-Chlorophenol and diethanolamine were used to from the ectatic solvent. Then, experimental parameters such as: solvent type, solvent volume, pH, extraction time, temperature, salt addition were optimized. The figure of merit of the method was also checked. The linear range was obtained in the range of 20-350 μg/L. Also, the repeatability of the method in one day and in 5 working days was obtained as 5.6 and 6.8, respectively. Also, the method of liquid-liquid microextraction with changeable hydrophilic solvent was studied and investigated for the extraction of imipramine. Effective factors for extraction such as solvent type, solvent volume, pH, extraction time, temperature, addition of salt were studied and evaluated and their figures of merit were calculated. In this method, the linear limit was obtained in the range of 20-350 μg/liter. Also, the repeatability of the method was obtained in one day and in 5 working days respectively 5.2 and 6.3.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Pharmaceutical compounds, Gas chromatography-mass spectrometry, Liquid phase microextraction, Eutectic solvents, Switchable hydrophilicity solvents |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 03 Jan 2024 07:37 |
| Last Modified: | 03 Jan 2024 07:37 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3472 |
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