Akbari, Aliakbar (2022) Investigating the protective effects of coenzyme Q10 against oxidative stress damage caused by thioacetamide on testicular tissue and liver and kidney biochemical parameters in male Wistar rats. Doctoral thesis, university of zabol.
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Investigating the protective effects of coenzyme Q10 against oxidative stress damage caused by thioacetamide on testicular tissue and liver and kidney biochemical parameters.pdf Download (197kB) | Preview |
Abstract
The issue of infertility has been one of the most important issues in the world that have focused a lot of research work, but still 15% of the world's population is involved in the issue of infertility. The share of male infertility is about 25%, which is a significant amount. Studies have shown that about 60% of infertility factors in men are due to oxidative damage, which is the result of an imbalance between the antioxidant capacity of the testicular tissue and oxidants that affect the testicular tissue in different ways. The purpose of this study was to investigate the antioxidant properties of coenzyme Q10 against the oxidative damage of thioacetamide on testicular tissue and biochemical parameters of the liver and kidney. Thioacetamide is a compound with high oxidative properties so a single-dose injection can cause acute liver damage. Coenzyme Q10 is a compound with high antioxidant properties that is used as an antioxidant in the treatment of infertility and chronic diseases. In this research, 20 male Wistar rats were used in 4 groups (a.b.c.d). group a as control, group b thioacetamide at a dose of 200mg/kg intraperitoneally, twice a week, group c coenzyme Q10 at a dose of 10mg/kg orally and group d the combination of coenzyme Q10 and thioacetamide with the indicated doses they received. The results of serum tests showed that the levels of alanine transaminase and aspartate transaminase (AST-ALT) increased significantly in the group that only received thioacetamide. While the changes of liver enzymes were much less in the group that also consumed Q10. The levels of blood urea nitrogen and serum creatinine (BUN-Scr) were also evaluated and no significant increase compared to the control group was observed in any of the groups. The data were statistically analyzed in SPSS software and the significance of changes in liver enzymes was proved (P<0.05). Examination of the testicular tissue also showed significant tissue damage of the spermatogenic tubules in the group that received only thioacetamide, while the tissue changes were very small in the group that received coenzyme Q10 along with thioacetamide. The neutralization of the oxidative effects of thioacetamide by coenzyme Q10 indicates the very strong antioxidant properties of this substance, which can neutralize free radicals caused by acute and chronic inflammatory processes, as well as oxidative substances that humans inevitably come into contact with daily.
| Item Type: | Thesis (Doctoral) |
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| Uncontrolled Keywords: | thioacetamide, coenzyme Q10, male Wistar rat, testicular tissue, liver, kidney |
| Subjects: | S Agriculture > SF Animal culture |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 12 Sep 2023 06:18 |
| Last Modified: | 12 Sep 2023 06:18 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3356 |
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