Arab, Mostafa (2022) Green synthesis of 5-substituted-3-amino-1,2,4-triazoles derivatives in deep eutectic solvents and the evaluation of their antimicrobial and antioxidant effects. Masters thesis, university of zabol.
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Green synthesis of 5-substituted-3-amino-1,2,4-triazoles derivatives in eutectic solvents and the evaluation of their antimicrobial and antioxidant effectsdeep.pdf Download (284kB) | Preview |
Abstract
One of the goals of green chemistry is to use eco-friendly solvents. In this study, a new process has been presented under green chemistry conditions for the synthesis of 5-substituted 3-amino-1,2,4-triazole derivatives in deep eutectic solvents. Triazole derivatives were prepared from the reaction of hydrazide derivatives with urea in the absence of acidic and basic catalysts in eco-friendly deep eutectic solvents. The products were synthesized in good to excellent yields under easy work-up and purification conditions. The antibacterial effects of these products were evaluated through Kirby Bauer disc diffusion sensitivity test. Acceptable to significant inhibitory activity was observed with synthesized 3-amino-1,2,4-triazole derivatives. The results showed that 5(4-tert-butylphenyl)1,2,4-triazole-3-amine and 5(3-bromo-phenyl)1,2,4-triazole-3-amine are two broad-spectrum antimicrobial agents.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | 1,2,4-triazole, antimicrobial agents, green chemistry, deep eutectic solvents |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 31 Jan 2023 07:01 |
| Last Modified: | 31 Jan 2023 07:01 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/3274 |
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