A study of the interaction space of lactate dehydrogenase isoforms and its some inhibitors using proteochemometric

Damavandi, Sedigheh (2021) A study of the interaction space of lactate dehydrogenase isoforms and its some inhibitors using proteochemometric. Masters thesis, University of Zabol.

[img]
Preview
Text
A study of the interaction space of lactate dehydrogenase isoforms and its some inhibitors using proteochemometric modeling.pdf

Download (153kB) | Preview

Abstract

Lactate dehydrogenase (LDH) is a tetramer enzyme that reversibly catalyzes the conversion of pyruvate to lactate. This enzyme is important because LDH isoenzymes are associated with a variety of diseases, including cancers, heart disease, liver problems, and most importantly, corona disease. The aim of this study was to model LDHA and LDHB isoenzyme inhibitors using proteochemetric method. This method is system-based and does not require knowledge of the three-dimensional structure of the protein, but it depends on the sequence of amino acids and descriptors. To implement the proteochemetric method, the camb package in the R Studio Server programming environment as well as the data set of LDHA and LDHB isoenzyme inhibitors from the valid Biniding DB database were used. The proteochemometric method uses three machine learning algorithms gradient amplification model, random forest and support vector machine as regression methods to find the best model. Finally, by examining the statistical parameters such as RMSE, R2 and Q2, the most appropriate model for inhibitors of LDHA and LDHB isoenzymes was selected using the best random forest method.

Item Type: Thesis (Masters)
Uncontrolled Keywords: descriptor, proteochemetric, machine learning algorithm, inhibitor, isoenzyme, camb package
Subjects: Q Science > QH Natural history
Depositing User: Mrs najmeh khajeh
Date Deposited: 18 Sep 2022 07:19
Last Modified: 18 Sep 2022 07:19
URI: http://eprints.uoz.ac.ir/id/eprint/2970

Actions (login required)

View Item View Item