Abdollahy, Hossein (2020) The joint effect of genomic selection and promotion of alleles by genome editing on improvement of quantitative traits in animal breeding programs. Doctoral thesis, University of Zabol.
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The joint effect of genomic selection and promotion of alleles by genome editing on improvement of quantitative traits in animal breeding programs.pdf Download (143kB) | Preview |
Abstract
heritability was increased and the trait specific heritability decreased. The accuracy of estimation breeding values in model 1 was the lowest and in models 3 to 6 was the same. Model 5 with the lowest false positive QTN and the highest true positive proportion was the appropriate model for genetic evaluation of the studied traits. By including polygenic and non-additive effects in the model, the number of false positive errors was reduced. The effect of promotion alleles by genome editing was effective on genomic variance and increased additive variance. When 1 QTNe was promoted and inherited by one generation to offspring, the increase in variance relative to genome selection increased by 0.139, and with the promotion of more alleles (20, 25, and 50 QTNe) over 20 generations, the variance increased. The response to cumulative selection in GS + PAGE mode increased by 0.07 when promoted in 5 bulls and 1 QTN in each one. When 20 and 50 QTNs were promoted, the cumulative response to genomic editing increased by 0.17 and 0.31, respectively. It seems that the response to cumulative selection is increased by increasing the frequency of alleles desirable for the desired trait that can be transmitted to the next generation. With increasing the number of QTNe, the inbreeding coefficient also increased slightly, but there was no significant difference between the inbreeding coefficient in the case of 20 QTNe and 25 QTNe when 5 males were edited and 10 males were edited at the same time. The effect of promotion alleles by genome editing was effective on genomic variance and increased additive variance. When 1 QTNe was promoted and inherited by one generation to offspring, the increase in variance relative to genome selection increased by 0.139, and with the promotion of more alleles (20, 25, and 50 QTNe) over 20 generations, the variance increased. The response to cumulative selection in GS + PAGE mode increased by 0.07 when promoted in 5 bulls and 1 QTN in each one. When 20 and 50 QTNs were promoted, the cumulative response to genomic editing increased by 0.17 and 0.31, respectively. It seems that the response to cumulative selection is increased by increasing the frequency of alleles desirable for the desired trait that can be transmitted to the next generation.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Uncontrolled Keywords: | Dairy Cattle, Genomic selection, Variance components, Bayes Lasso, Nonadditive effects, promotion of alleles, genome editing |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 27 Oct 2021 07:59 |
| Last Modified: | 27 Oct 2021 07:59 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/2889 |
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