Fazlipour, Iman (2015) Determination of Atorvastatin in aqueous samples using dispersive liquid-liquid microextraction method optimized by experimental design pattern. Masters thesis, University of Zabol.
|
Text
Determination of Atorvastatin in aqueous samples using dispersive liquid-liquid.pdf Download (296kB) | Preview |
Abstract
In this work, a new, simple and fast dispersive liquid-liquid micro extraction method coupled with high performance liquid chromatography was used to extract atorvastatin. For this extraction, 40μl of undecanol as extraction solvent and 1.5ml methanol as dispersive solvent was added to sample. After addition of undecanol and methanol, an unsteady cloudy phase is formed and separates from the solution that stays on top of solvent which can be easily separated. The extracted solvent is injected to HPLC for further analysis. The effects of various experimental in extraction step with using design of experimental were also studied using response surface methodology. Three independent variables were volume of extraction solvent, volume of dispersive solvent and Ph. In optimum condition, linear rang achieved were 3-200 μg/l , R2=0.994, RSD= 4.1 and limit of detection (LOD)= 0.9. This method was used for determination of atorvastatin in tablet.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Dispersive Liquid-Liquid Micro extraction, atorvastatin, design of experimental, response surface methodology, High Performance Liquid Chromatography |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | admin admin1 admin2 |
| Date Deposited: | 13 Apr 2016 06:05 |
| Last Modified: | 13 Apr 2016 06:05 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/284 |
Actions (login required)
 |
View Item |
