Davoodi, Hoda (2019) Synthesis, identification and comparison of chemical and physical preparation methods of gold nanoparticles in the presence of organic reducing agents and their interactions with CT-DNA. Masters thesis, University of Zabol.
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Abstract
in this study, Therefore, in this study, the effect of change reducing agent and various chemical and mechanical methods on the size and stability of gold nanoparticles, as well as the interaction of these nanoparticles with DNA of calf thymus tuber, were investigated. According to the analyses and the results, the method used in the presence of tri-sodium citrate, poly ethylene glycol and microwave was selected as the optimal method because the nanoparticles produced by this method have spherical shape and the highest degree of stability and efficiency due to the use of peptide. the nanoparticles synthesized by this method for experiments involving the interaction of gold nanoparticles with DNA of calf thymus gland (CT-DNA) using the UV-Vis spectroscopy technique was studied at 300 and 310 K temperatures. The amount of [L]1 2 resulted in a small amount, indicating that if this compound is used as an anticancer drug. A small amount of doses is needed, therefore, complications reduces the side effects of the drug. Binding parameters such as g, K, n, ν and thermodynamic parameters such as m,
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Gold nanoparticles, peptid, anticancer, DNA binding studies, binding parameters, thermodynamic parameters |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 06 May 2019 08:18 |
| Last Modified: | 06 May 2019 08:18 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/2439 |
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