Evaluation of BRCA1 gene expression in tumor tissue of esophagus cancer by RT-qPCR

Mir, Mahdiyeh (2014) Evaluation of BRCA1 gene expression in tumor tissue of esophagus cancer by RT-qPCR. Masters thesis, university of zabol.

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Esophageal cancer is one of the most common malignancies in different regions of Iran. The recognition and evaluation of tumor-forming mechanisms and, in particular, the role of important tumor-forming genes (oncogenes) and tumor suppressor genes are of great importance in this disease.The. BRCA1 and BRCA2 genes are one of the most important genes in controlling mutations and changes in cancer. These genes recover the failures which occur in DNA. The present study aims to investigate the changes in BRCA1 expression in esophageal cancer patients. Thirty paraffin-embedded tissue samples of normal esophageal and cancer tissues were analyzed to measure the BRCA1 expression. The real time-PCR reactions for BRCA1 and β-actin were carried out by the Livac method. All data were analyzed by SPSS 13 (SPSS, Inc., Chicago, IL) software. The results showed that BRCA1 expression in tumor samples decreased compared to the control (p<0.05).

Item Type: Thesis (Masters)
Uncontrolled Keywords: Esophageal cancer, Real time-PCR, BRCA1
Subjects: Q Science > QH Natural history > QH426 Genetics
Depositing User: Mrs najmeh khajeh
Date Deposited: 10 Apr 2018 04:59
Last Modified: 02 Mar 2019 06:40
URI: http://eprints.uoz.ac.ir/id/eprint/1998

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