Kiani shahvandi, Siamak (2017) Development of a new pH assisted homogeneous liquid-liquid microextraction method based on switchable-hydrophilicity solvents: application for preconcentration of methamphetamine and its determination with GC-MS analysis. Masters thesis, university of zabol.
|
Text
Development of a new pH assisted homogeneous.pdf Download (449kB) | Preview |
Abstract
In this study, a new pH assisted homogeneous liquid-liquid microextraction method based on Switchable-Hydrophilicity Solvents followed by gas chromatography-Mass spectrometry detection has been developed for preconcentration and determination of methamphetamine in urine sample. The extraction technique makes use of a waterimmiscible solvent (N,N-Dipropylamine) that can be solubilized in the aqueous phase in 1:1 ratio using HCL as a reagent. Afterwards, phases separation is induced by the addition of sodium hydroxide. The extraction technique has been optimized and characterized using the determination of methamphetamine by gas chromatography Coupled with mass spectrometry in water samples. series of parameters that influence extraction were investigated systematically. The effects of operational parameters of the extraction such as volume of acceptor phase, volume of donor phase, temperature, pH of donor phase, and ionic strength of solution were investigated. Under optimal conditions, good linear relationship of methamphetamine was obtained in the range 5.0– 1500.00 μgL-1, the limit of detection were1.5 μgL-1, and the enrichment factor was 87. Finally, The proposed method allows the determination of the target analytes at the low microgram per liter range with acceptable precision.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Methamphetamine, Homogeneous liquid–phase microextraction, Switchable hydrophilicity solvent, N,N-Dipropylamine |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | Mrs najmeh khajeh |
| Date Deposited: | 10 Apr 2018 06:53 |
| Last Modified: | 04 Mar 2019 05:13 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/1973 |
Actions (login required)
 |
View Item |
