Association study of rs744166 SNP in STAT3 gene with multiple sclerosis in East of Iran

Rafee Sheikhi, R. (2014) Association study of rs744166 SNP in STAT3 gene with multiple sclerosis in East of Iran. Masters thesis, University of Zabol.

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Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with an unknown etiology. The prevalence of MS in various geographical and ethnical groups is very different; Iran is located in low range of MS. Unfortunately in recent years, the rate of MS increased in Iran. Reports proposed that, Iran will have many new cases of MS and will be located in moderate rate of MS in the future. Signal transducer and activator of transcription 3 (STAT3) gene located on chromosome 17q21.1, codes a nuclear transcription factor and was identified as a putative new multiple sclerosis (MS) susceptibility locus in Genome wide association studies. STAT3 codes for a transcription factor that is involved in multiple pathways and functions include Jak-STAT pathway, neuron axonal guidance, apoptosis, activation of immune responses, and Th17 cell differentiation. In this study we tried to find the association of rs744166 SNP polymorphisms in STAT3 gene with MS susceptibility in eastern parts of Iran. A case-control study was handled with 204 MS patients and 202 age and gender matched controls using PCR-RFLP strategy for (rs744166) SNP of STAT3 gene. Statistical analysis was done using SPSS version19 (SPSS Inc., Chicago, IL).Genotypic and allelic frequencies were compared between patients and controls using the Chi-Square Tests. Results showed significance correlation between rs744166 SNP located in intron 1 of STAT3 gene and MS disease

Item Type: Thesis (Masters)
Uncontrolled Keywords: Multiple sclerosis, STAT3, Polymorphism, rs744166, SNP
Subjects: Q Science > QH Natural history > QH426 Genetics
Depositing User: admin admin1 admin2
Date Deposited: 03 Apr 2016 06:21
Last Modified: 03 Apr 2016 06:21

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