Rezaei, Meysam (2015) The study of poly-substituted heterocyclic pyrazole derivatives synthesis under novel green conditions in the presence of new deep eutectic solvents. Masters thesis, University of zabol.
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Abstract
Pyrazole derivatives have been considered as a very important class of heterocycles possessing a five membered ring with two adjacent nitrogen atoms. Herein, a novel efficient and robust methodology for the synthesis of pyrazole-4- carbonitrile derivatives using multicomponent reaction of malononitrile, benzaldehyde and hydrazine derivatives in the presence of deep eutectic solventsas medium and promoter is reported. This novel class of green solvents have found application in organic synthesis. The present methodology provides valuable pyrazole-4-carbonitrile derivatives in high to excellent yields within very short reaction times. A plethora of deep eutectic solvent mixtures were applied and Urea/Cholie chloride mixture was found as the best solvent of choice for this process. No need for extra oxidant and catalyst, not using any toxic organic solvents simple work-up and low reaction temperature were among the advantages of this protocol over the previously reported methods.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Pyrazole-4-carbonitrile, Multi-Component Reaction, Deep eutectic solvent, Green solvent |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | admin admin1 admin2 |
| Date Deposited: | 18 Jun 2017 05:52 |
| Last Modified: | 18 Jun 2017 05:52 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/1570 |
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