Genetic and Medical Evaluation of Age-Related Dementia in Elderly Iranians of Sistan

Pordel, Amineh (2016) Genetic and Medical Evaluation of Age-Related Dementia in Elderly Iranians of Sistan. Masters thesis, University of Zabol.

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A degree of age-related dementia has been well documented in almost all eukaryotes including human being. Symptomatic stages of dementia are manifested at later ages of life. There are several environmental and genetic factors leading to neuronal death in elderly individuals. In the present study, for the first time in Sistan and Baluchestan province, status of the environmental factors including lifestyle parameters and a genetic known genetic risk factor for Alzheimer’s disease, APOE, has been investigated. There were 55 affected and 70 healthy individuals in our study. After screening of target population according to standard MMSE test and Sistani ethnics, Blood samples were drawn and used to determine lipid profile and few metal ion levels of each individual participated in the study. The DNA samples were also isolated from peripheral blood samples and underwent allele specific PCR (AS PCR) for APOE genotyping. Our results showed a noticeable increase in allelic frequency of APOE E4 among cases. The blood HDL level of cases was markedly lower than that of controls while Cu ion has a higher level in peripheral blood samples of cases when compared to healthy control individuals. Moreover, most of the affected people were illiterate and were in drug abuser. Other factors displayed no differences between the two groups.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Elder, dementia, APOE gene, AS PCR
Subjects: Q Science > QH Natural history > QH426 Genetics
Depositing User: admin admin1 admin2
Date Deposited: 17 Apr 2017 05:19
Last Modified: 17 Apr 2017 05:19

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