Pourian, Mohammad Ali (2016) Novel methods for green synthesis of six-membered Heterocyclic fused rings from cyclic compounds containing active methylene. Masters thesis, University of Zabol.
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Abstract
A simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of fused six membered highly saturated chromene derivatives. These compounds have shown diverse medicinally important effects such as anti-coagulant, anti-spasmodic, antibacterial, anti-HIV, the use of MCM-41-Pr-NH2 based nanocatalysts for the preparation of organic molecules has been emerged as a vital and progressive area of research in recent years. In the recent work, the condensation of various aldehydes, dimedone and malononitrile in the ratio of 1: 1: 1.2 mmol respectively in the presence of a MCM-41-Pr-NH2 based nanocatalyst under solvent-free conditions is reported. The reaction was well performed at ambient temperatures (70 oC) and the 2-amino-7,7-dimethyl-8 oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3- carbonitrile and 7-amino-2,4-dioxo-5-phenyl-1,3,4,5-tetrahydro-2H-pyrano[2,3- d]pyrimidine-6-carbonitrile products were easily separated from the nanocatalyst by dissolving in ethanol and simple filtration. Relatively short reaction times, no need to extra harmful organic solvent, high yields and reusability of the catalyst were among the other advantages of the present protocol. Kind’s eutectic solvents conditions without catalyst MCM-41-Pr-NH2 at were efficiently used for the preparation of derivatives...
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Barbituric acid, Dimedone, Green Chemistry, MCM-41-Pr-NH2, multicomponent reaction |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | admin admin1 admin2 |
| Date Deposited: | 19 Dec 2016 08:14 |
| Last Modified: | 19 Dec 2016 08:14 |
| URI: | http://eprints.uoz.ac.ir/id/eprint/1142 |
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